Adrenocorticotropic Action of Antidiuretic Hormone

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Adrenocorticotropic action of antidiuretic hormone.

By means of direct arterial perfusion of the adrenal glands of the hypophysectomized dog, it has been shown that synthetic lysine, arginine and acetyl arginine vasopressins stimulate the adrenal cortex directly to secrete hydrocortisone. Pressor activity and cortisol-stimulating activity were demonstrated to be independent of each other. Similar polypeptides, such as oxytocin, insulin, glucagon...

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Adrenocorticotropic Action of Antidiuretic Hormone

By means of direct arterial perfusion of the adrenal glands of the hypophysectomized dog, it has been shown that synthetic lysine, arginine and acetyl arginine vasopressins stimulate the adrenal cortex directly to secrete hydrocortisone. Pressor activity and cortisol-stimulating activity were demonstrated to be independent of each other. Similar polypeptides, such as oxytocin, insulin, glucagon...

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Role of antidiuretic hormone in hyponatremia in patients with isolated adrenocorticotropic hormone deficiency.

We found symptomatic hyponatremia in four elderly patients in which serum sodium (Na) levels ranged from 101 to 122 mEq/l. All 4 patients had low levels of plasma adrenocorticotropic hormone (ACTH), serum cortisol, and urinary excretion of 17-OHCS, and poor responses of ACTH to exogenous insulin and antidiuretic hormone (ADH). Other pituitary hormones were all normal. They were therefore diagno...

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Studies on the mechanism of action of the adrenocorticotropic hormone.

It has been demonstrated that adrenocorticotropic hormone (ACTH) stimulates isolated, perfused adrenal glands (1) and adrenocortical tissue slices (2, 3) to release increased quantities of corticosteroid hormones. These findings are in accord with the well established fact that ACTH in tivo causes the adrenal cortex to secrete increased quantities of the adrenal steroid hormones. The present wo...

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The effect of adrenocorticotropic hormone in panhypopituitarism.

A priori one would anticipate that the effects of a hormone would be most apparent when given to an individual lacking that hormone. To be sure, when the hormone acts through another gland, as does adrenocorticotropic hormone (ACTH), one might find the "target" gland unresponsive through atrophy. In panhypopituitarism, one is dealing not with a single deficiency, but with a deficiency of all "t...

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ژورنال

عنوان ژورنال: Circulation

سال: 1960

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.21.5.1038